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2014-11-24 Original derivatives of Imidazo[1,2-b]pyrazoles

In order to provide new and original chemical compounds to our customers, Greenpharma/Ambinter has developed innovative synthesis routes with partners. For example, C7 or C3/C7 Direct Arylation of Tri- or Disubstituted Imidazo[1,2-b]pyrazoles are now available in Ambinter catalogue.

You can find more information on the publication (abstract below) in Synlett, 2013, 24 (16), 2095-2101.

Efficient C7 or C3/C7 Direct Arylation of Tri- or Disubstituted Imidazo[1,2-b]pyrazoles
A novel and efficient method of C-7 direct arylation of the imidazo[1,2-b]pyrazole core, never described to date, is presented in this paper. Series of electron-rich or electron-poor aryl and heteroaryl groups were easily introduced. The corresponding products were obtained in moderate to excellent yields thanks to this pallado-catalyzed and microwave-assisted process. A one-pot double C-3 and C-7 direct coupling is also reported.
imidazo12b-pyrazoles

Click on the link to display the structures of imidazo[1,2-b]pyrazoles library.


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